The simplest way to get to the Bolshoi from the Assambleya Nikitskaya Hotel is on foot, and the walk should take less than ten minutes. Turn left out of the hotel and walk to the end of Bolshaya Nikitskaya Ulitsa. Turn left again along Mokhovaya Ulitsa and follow the street round (using the underpass to cross Tverskaya Ulitsa) until you reach Teatralnaya Ploshchad, the square in front of the Bolshoi Theater.
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