The Holiday Inn Simonovsky is only five minutes' drive (or 20 minutes' walk) from Pavelets Railway Station, making it very convenient for the Aeroexpress rail link to/from Domodedovo Airport. Moscow's other mainline railway stations can all be reached in 20-30 minutes by car.
If you choose to take a taxi, the drive from Domodedovo will take just under an hour in reasonable traffic conditions. Moscow's other two international airports, Sheremetyevo and Vnukovo, are slightly closer, but on opposite sides of the city from the Holiday Inn Simonovsky, so traffic is more likely to be a problem.