By taxi
The drive to the Los Hotel should not take more than 40 minutes, and taxis at the station can be negotiated for around $50. Due to the out-of-the-way location of the hotel, however, it is probably better to book a transfer in advance, which you can do here.
By metro
From Kievskaya Metro Station (accessed from the mainline station concourse) travel clockwise on the brown circle line four stops to Prospekt Mira, and there change to the orange line and travel six stops to Babushkinskaya. From there it is around 2 km to the Los Hotel. Exit the station from the front of the train and bear right out of the underpass to find the stop for the No. 605 bus. This will take you to Chelyuskinskaya Ulitsa Meditsinskiy Kolledzh Bus Stop, about 200m from the Los Hotel.